Thaum Lub Kaum Ib Hlis 9, 2021, qhov sib txawv ntawm covkhaus laus nas vais lav tawm tshiabB.1.1.529 tau kuaj pom thawj zaug los ntawm ib qho piv txwv ntawm South African kis.Hauv tsawg dua 2 lub lis piam, cov kab mob sib kis tau dhau los ua qhov tseem ceeb ntawm kev hloov pauv ntawm South Africa cov kab mob tshiab, thiab nws txoj kev loj hlob sai tau ua rau muaj kev cuam tshuam thoob ntiaj teb.Thaum Lub Kaum Ib Hlis 26, qhov kev hloov pauv no tau txhais los ntawm WHO tias yog qhov thib tsib "kev txhawj xeeb ntawm kev txhawj xeeb" (VOC), lub npe hu ua Omicron (Omicron) mutant.Tam sim no, Omicrom tus kab mob sib txawv tau kis mus rau 19 lub teb chaws lossis cheeb tsam thoob plaws ntiaj teb, thiab tuaj yeem ua rau muaj kev nyuaj siab tshiab rau kev tiv thaiv thiab tswj kev kis thoob ntiaj teb.
Lub koom haum WHO kuj tau hais tias Omicron muaj ntau qhov kev hloov pauv, qee qhov kev txhawj xeeb.Lub koom haum WHO tseem tau hais tias "Omicron" cov kab mob hloov pauv tau kuaj pom sai dua li lwm hom kab mob sib kis uas tau ua rau muaj kev kis kab mob yav dhau los, qhia tias qhov kev hloov pauv tshiab no tuaj yeem muaj txiaj ntsig zoo.Kev nruj nruj tiv thaiv kev sib kis ntawm kev hloov pauv ntawm tus kabmob tshiab Omicron tau dhau los ua lub hom phiaj tshiab rau kev tiv thaiv kabmob kis thoob ntiaj teb
Hloov pauv daim ntawv qhia ntawm Omicron(1)thiab Delta(2), Stanford University Coronavirus thiab Drug Resistance Database
Ntxiv rau qhov muaj ntau qhov kev hloov pauv hauv cov protein ntau, Omicron mutant strain kuj muaj ntau qhov chaw hloov pauv hauv N protein.Txij li lub hom phiaj tseem ceeb ntawm tus tshiab coronavirus antigen detection reagent yog N protein, kev hloov pauv ntawm N protein yuav cuam tshuam rau tus kabmob tshiab antigen.Qhov tseeb ntawm cov khoom siv kuaj muaj qhov cuam tshuam.
| Table 1. Kev sib piv ntawm N protein evolution ntawm txawv mutants
| |
| Hom kab mob vais lav
| N protein evolution |
| Alpha(B.1.1.7) | r203k ua.G204R; (> 50%) S194L (5-50%) D3H; D63G; T205I; M234I (1-5%) |
| Beta (B.1.351) | T205I (> 50%) P13S; T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma (p.1) | P80R; S202C; R203K; G204R (> 50%) A211S; D402Y; S4131 (1-5%) |
| Delta(B.1.617.2) | D63G; R203M; G215C; D377Y (> 50%) Q9L (> 5-50%) G18V; R385K (1-5%)
|
| Omicron (B.1.1.529) | P13L; R203K; G204R E31/R32/S33 Del |
Piv nrog Alpha-N protein, Omicron-N protein muaj qhov sib txawv ntawm 10 amino acid txoj haujlwm.Txhawm rau tshawb xyuas qhov kev kuaj pom ntawm Omicron-N protein los ntawm covid-19 antibody raw khoom ntawm Keygen gene, peb npaj recombinant Omicron-N protein nyob rau hauv thawj zaug, Thiab ua kev sib koom ua pov thawj los ntawm Keygen Gene thiab ib tug xov tooj ntawm cov neeg muas zaub.Cov txiaj ntsig tau pom tias qhib cov noob tshiab cov khoom siv tshuaj tiv thaiv kab mob muaj cov txiaj ntsig zoo ib yam rau cov recombinant Omicron-N protein, Alpha-N protein thiab Delta-N protein.Qhov qhib pom cov khoom siv tshuaj tiv thaiv kab mob tshiab tuaj yeem ua kom qhov tseeb ntawm cov khoom siv tshuaj tiv thaiv kab mob tshiab tshiab rau kev tshawb pom ntawm Omicron variants..
| Table 2 Cov txiaj ntsig ntawm kev tshawb pom ntawm Omicron recombinant N protein los ntawm neocorona antibody | ||||||
| Antibody Ua khub | Alpha-Nprotein | Omicron-Nprotein | ||||
| 4.0 ng/ml | 2.0 ng/ml | 1.0 ng/ml | 4.0 ng/ml | 2.0 ng/ml | 1.0 ng/ml | |
| Npaj 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Npaj 2 | G5 | G4 | G2 | G5 | G4 | G2 |
Colloidal kub zaub qhov sib piv daim npav
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Post lub sij hawm: Dec-14-2021
