IVD reagent khoom Cardiac marker

Cardiac Troponin I (cTnI) yog ib hom subtype ntawm tsev neeg troponin uas feem ntau siv los ua tus cim rau kev puas tsuaj ntawm myocardial.Cardiac troponin I yog qhov tshwj xeeb rau cov ntaub so ntswg plawv thiab kuaj pom hauv cov ntshav tsuas yog tias muaj mob myocardial tshwm sim.Vim hais tias lub plawv troponin kuv yog ib qho rhiab heev thiab qhia tshwj xeeb ntawm lub plawv cov leeg (myocardium) kev puas tsuaj, cov qib ntshav tuaj yeem siv los pab sib txawv ntawm qhov tsis ruaj tsis khov angina thiab myocardial infarction (lub plawv nres) hauv cov neeg mob hauv siab lossis mob plawv.

Lub plawv isoform ntawm TnT yog dav siv los ua tus cim ntawm myocardial cell raug mob, ib yam li cTnI.cTnT muaj tib qhov tso tawm kinetics rau hauv cov hlab ntsha thiab tib lub rhiab heev rau cov mob me me ntawm myocardial li cTnI.Hauv cov ntshav ntawm cov neeg mob myocardial infarction (AMI), cTnT feem ntau pom nyob rau hauv daim ntawv pub dawb thaum cTnI feem ntau pom nyob rau hauv complex nrog TnC.

Troponin C, tseem hu ua TN-C los yog TnC, yog ib qho protein uas nyob hauv troponin complex ntawm actin nyias filaments ntawm striated nqaij (lub plawv, ceev-twitch skeletal, los yog qeeb-twitch skeletal) thiab yog lub luag hauj lwm rau khi calcium kom qhib tau. nqaij contraction.Troponin C yog encoded los ntawm TNNC1 noob nyob rau hauv tib neeg rau ob lub plawv thiab lub cev pob txha qeeb.

myoglobin yog ib qho cytoplasmic protein uas khi cov pa ntawm ib pawg heme.Nws tsuas muaj ib pawg globulin xwb, thaum hemoglobin muaj plaub.Txawm hais tias nws pawg heme zoo ib yam rau cov neeg hauv Hb, Mb muaj kev sib raug zoo rau cov pa oxygen ntau dua li cov hemoglobin.Qhov sib txawv no muaj feem xyuam rau nws lub luag haujlwm sib txawv: thaum hemoglobin thauj oxygen, myoglobin txoj haujlwm yog khaws cov pa.

Digoxin yog siv los kho lub plawv tsis ua hauj lwm, feem ntau nrog rau lwm yam tshuaj.Nws kuj tseem siv los kho qee yam ntawm lub plawv dhia tsis xwm yeem (xws li mob atrial fibrillation).Kev kho mob plawv tsis ua hauj lwm yuav pab tswj koj lub peev xwm taug kev thiab tawm dag zog thiab tuaj yeem txhim kho koj lub siab lub zog.Kev kho lub plawv dhia tsis tu ncua kuj tuaj yeem txhim kho koj lub peev xwm ua haujlwm.Nws ua haujlwm los ntawm kev cuam tshuam qee cov zaub mov (sodium thiab potassium) hauv lub plawv hlwb.Qhov no txo ​​qis kev nyuaj siab ntawm lub plawv thiab pab nws tswj lub plawv dhia zoo li qub, khov kho, thiab muaj zog.

CK-MB nyob rau hauv mob myocardial infarction (AMI), thiab CK-BB nyob rau hauv lub hlwb puas thiab malignant qog ntawm lub plab hnyuv ib ntsuj av.CK-MB yog ntsuas los ntawm kev ua haujlwm enzyme lossis kev ua haujlwm loj thiab ntsuas raws li tus cim tsis yog hauv kev kuaj mob ntawm AMI nkaus xwb tab sis kuj nyob rau hauv qhov xav tias AMI thiab tsis ruaj khov angina.

Lub plawv-hom-Fatty-Acid-Binding-Protein (hFABP) yog cov protein, uas yog koom nrog hauv kev thauj mus los hauv lub cev (Bruins Slot li al., 2010; Reiter li al., 2013).Tom qab myocardial necrosis hFABP tau tso tawm sai sai rau hauv cov ntshav thiab yog li ntawd tau tshawb xyuas raws li biomarker rau AMI.Txawm li cas los xij, vim qhov tsis tshua muaj siab thiab qhov tshwj xeeb hFABP tsis tau ua pov thawj muaj txiaj ntsig, piv rau kev kuaj mob ntawm hs-Tn kev soj ntsuam (Bruins Slot li al., 2010; Reiter li al., 2013).

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

Lipids yog cov rog hauv koj cov ntshav.Lipoproteins yog kev sib txuas ntawm cov rog thiab cov proteins uas nqa cov rog hauv koj cov hlab ntsha.Yog tias koj muaj Lp-PLA2 hauv koj cov ntshav, tej zaum koj yuav muaj cov rog rog hauv koj cov hlab ntsha uas muaj kev pheej hmoo ntawm kev tawg thiab ua rau mob plawv lossis mob stroke.

D-dimer (lossis D dimer) yog cov khoom lag luam fibrin degradation (lossis FDP), ib qho me me ntawm cov protein nyob hauv cov ntshav tom qab cov ntshav txhaws tau degraded los ntawm fibrinolysis.Nws yog lub npe vim hais tias nws muaj ob feem D ntawm fibrin protein koom nrog kev sib txuas.